

Openverse
Top 10 US Digital Health Startups
The US digital health market exceeded $50B in 2023 and is projected to reach $140B by 2028, driven by consumer demand for telehealth, mental health support, chronic disease management, and employer-sponsored wellness platforms. COVID-19 normalized virtual care and unlocked regulatory flexibility that persists into 2026, while GLP-1 obesity drug demand has turbocharged metabolic health platforms. Key players are building longitudinal health relationships with tens of millions of Americans outside the traditional clinical system, compressing costs while improving access for underserved populations.
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Frequently Asked Questions About US Digital Health Startups
What counts as a digital health startup? A company that delivers health care, wellness, or insurance-navigation services primarily through software — apps, telehealth platforms, or remote monitoring — rather than in-person facilities.
Which US digital health startup is the largest by users? Hims & Hers Health leads on subscriber scale with 1.5M+ paying subscribers, while Noom reports 50M+ global users across its weight-management program.
Why is GLP-1 demand so important to digital health in 2025–2026? GLP-1 obesity drugs such as semaglutide created a need for companion coaching, nutrition, and longitudinal monitoring — a need startups like Calibrate were built to fill.
Are these startups profitable? Profitability varies; some are scaled subscription businesses, others are growth-stage. Valuations on this list range from $1B+ to $4.5B (Transcarent, 2024).
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