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The US digital health market is on track to surpass $500 billion by 2030, turbocharged by telehealth adoption, AI-driven diagnostics, and value-based care mandates. These 10 companies are digitizing every layer of healthcare — from patient records and virtual visits to genomics and employer navigation.
Curated by our tech editors. Practical, hands-on reviews weighted by community vote — updated as the field evolves.

The largest US telehealth provider with $2.6B revenue in 2023 and 90M+ members across 175 countries. Delivers 20M+ virtual visits per year spanning primary care, mental health, and chronic condition management. Acquired Livongo in 2020 for $18.5B to become the end-to-end virtual care leader.

The private EHR giant with $4.2B in revenue that controls 35% of the US electronic health records market. Its software stores records for 60% of US patients, spanning 300+ health systems. Founded in 1979 by Judy Faulkner, Epic remains entirely employee-owned in Verona, Wisconsin.

The cloud platform purpose-built for life sciences with $2.4B revenue in 2023 and a $34B market cap. Serves 1,000+ pharmaceutical and biotech clients with CRM, clinical trials, and regulatory data management tools. Converted to a public benefit corporation in 2021, balancing profit with public health mission.

The LinkedIn for physicians with $440M revenue in 2023 and 80% of US physicians on its platform. Offers secure messaging, telehealth tools, and career resources to a verified network of 2M+ healthcare professionals. Went public in 2021 at a $7.7B valuation, one of the largest healthcare IT IPOs ever.

A healthcare data analytics platform with $290M in revenue serving 800+ hospital clients with value-based care outcomes tools. Its DOS data platform aggregates 100B+ patient data points to drive measurable clinical and operational improvement. Went public in 2019 with a focus on reducing total cost of care.

An employer-facing health navigation platform valued at $4.5B in 2023 with $200M+ ARR. Guides employees to the highest-quality, most cost-effective care for surgery, cancer, and chronic conditions. Backed by a16z and General Catalyst, with former Livongo CEO Glen Tullman at the helm.

Formed by the 2021 merger of Grand Rounds and Doctor On Demand, Included Health serves 200+ employer clients with integrated virtual care and care navigation. Valued at $1.3B, it provides condition management, mental health, and specialist access to millions of covered employees and their families.

A direct-to-consumer telehealth and compounding pharmacy platform with $872M revenue in 2023 and 1.6M subscribers. Offers affordable treatments for hair loss, erectile dysfunction, mental health, and weight management. Went public via SPAC in 2021 and has built one of the largest telehealth subscriber bases in the US.

An AI-powered behavior change platform for weight management with $400M in revenue and 50M users enrolled since its 2008 founding. Uses cognitive behavioral therapy techniques and human coaching delivered via app to drive sustainable weight loss. Its subscription model commands $60+/month per user.

A precision medicine platform with $1B ARR combining genomic sequencing and AI for oncology diagnosis and treatment. Valued at $8.1B following its 2024 IPO, Tempus has built the world's largest library of clinico-genomic data. Partners with 7 of the top 10 cancer centers to match patients to clinical trials.
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The largest US telehealth provider with $2.6B revenue in 2023 and 90M+ members across 175 countries. Delivers 20M+ virtual visits per year spanning primary care, mental health, and chronic condition management. Acquired Livongo in 2020 for $18.5B to become the end-to-end virtual care leader.

The private EHR giant with $4.2B in revenue that controls 35% of the US electronic health records market. Its software stores records for 60% of US patients, spanning 300+ health systems. Founded in 1979 by Judy Faulkner, Epic remains entirely employee-owned in Verona, Wisconsin.

The cloud platform purpose-built for life sciences with $2.4B revenue in 2023 and a $34B market cap. Serves 1,000+ pharmaceutical and biotech clients with CRM, clinical trials, and regulatory data management tools. Converted to a public benefit corporation in 2021, balancing profit with public health mission.

The LinkedIn for physicians with $440M revenue in 2023 and 80% of US physicians on its platform. Offers secure messaging, telehealth tools, and career resources to a verified network of 2M+ healthcare professionals. Went public in 2021 at a $7.7B valuation, one of the largest healthcare IT IPOs ever.

A healthcare data analytics platform with $290M in revenue serving 800+ hospital clients with value-based care outcomes tools. Its DOS data platform aggregates 100B+ patient data points to drive measurable clinical and operational improvement. Went public in 2019 with a focus on reducing total cost of care.

An employer-facing health navigation platform valued at $4.5B in 2023 with $200M+ ARR. Guides employees to the highest-quality, most cost-effective care for surgery, cancer, and chronic conditions. Backed by a16z and General Catalyst, with former Livongo CEO Glen Tullman at the helm.

Formed by the 2021 merger of Grand Rounds and Doctor On Demand, Included Health serves 200+ employer clients with integrated virtual care and care navigation. Valued at $1.3B, it provides condition management, mental health, and specialist access to millions of covered employees and their families.

A direct-to-consumer telehealth and compounding pharmacy platform with $872M revenue in 2023 and 1.6M subscribers. Offers affordable treatments for hair loss, erectile dysfunction, mental health, and weight management. Went public via SPAC in 2021 and has built one of the largest telehealth subscriber bases in the US.

An AI-powered behavior change platform for weight management with $400M in revenue and 50M users enrolled since its 2008 founding. Uses cognitive behavioral therapy techniques and human coaching delivered via app to drive sustainable weight loss. Its subscription model commands $60+/month per user.

A precision medicine platform with $1B ARR combining genomic sequencing and AI for oncology diagnosis and treatment. Valued at $8.1B following its 2024 IPO, Tempus has built the world's largest library of clinico-genomic data. Partners with 7 of the top 10 cancer centers to match patients to clinical trials.
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