Boston claims #6 as a biotech and AI powerhouse, driven by MIT and Harvard talent pipelines that produce over 8,500 STEM graduates annually. The city secured $12.2 billion in venture capital in 2025, 15% more than the previous year, with AI companies alone raising $3.1 billion—a figure that beats #7 Denver’s total startup funding by 2.3x. Its cluster of 600+ biotech firms delivers clinical trials 30% faster than the national average, making it a top choice for life-science innovators despite higher living costs than #8 Raleigh-Durham.
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