Natural selection and evolution. Biology's most important unifying theory.
Darwin's theory of evolution by natural selection provided a unifying explanation for the entire diversity of life on Earth, a concept that outperforms #3 Marie Curie's radioactivity in biological impact. His 1859 work "On the Origin of Species" transformed biology from a descriptive science into an explanatory one, based on evidence from his five-year HMS Beagle voyage. Darwin observed over 1,000 species across South America and the Galapagos, collecting hundreds of specimens. His framework is faster than the typical creationist model at explaining patterns like antibiotic resistance. Specific data: Darwin's finches show beak-size evolution tracked at 5% change per decade. Modern genetics, ecology, and medicine rely on his evolutionary framework, with over 99% of biologists accepting his core theory as foundational.

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