Heavy compound lifts acutely spike testosterone and growth hormone, while chronic excessive endurance training can suppress these anabolic hormones and elevate cortisol by up to 30%. The interference effect documented in concurrent training research shows high-volume cardio blunts muscle protein synthesis signals by 20%, though moderate cardio enhances recovery between resistance sessions. These hormonal trade-offs make weight training superior for anabolic signaling, as it outperforms cardio in acute hormonal responses critical for muscle growth.

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