The Draize eye irritancy test has been a flashpoint in animal rights since 1944, when substances are applied to restrained rabbits' eyes. Despite use by top cosmetic companies, its cruelty galvanized a global movement. The test causes blinding pain in 70% of subjects, yet it set a benchmark for irritation data. Compared to #4, the Silver Spring monkeys case, which exposed filth, Draize is cheaper than the typical rival alternative at $2,000 per test, but in-vitro replacements now cut animal use by 50% in Europe since 2009. It ranks 30% lower in public approval than Harlow's #1 for scientific value, making it a prime target for reform.
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