Folate (Methylfolate, 5-MTHF)

Up to 40% of the population carries MTHFR gene variants that impair conversion of synthetic folic acid to its active form. Methylfolate (5-MTHF) bypasses this genetic bottleneck, directly supporting DNA repair, neurotransmitter synthesis, and homocysteine metabolism. It is essential for women of childbearing age, as adequate folate prevents 70% of neural tube defects.