Alpha-GPC

Alpha-GPC is the most bioavailable choline supplement, efficiently crossing the blood-brain barrier and rapidly increasing acetylcholine synthesis. RCTs in Alzheimer patients show meaningful improvements with 1200mg per day. For healthy adults 300 to 600mg is sufficient. Alpha-GPC may be slightly superior to citicoline for immediate choline delivery but lacks the cytidine component. Some users report headaches at high doses from excess cholinergic activity.