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mRNA Vaccine Technology
mRNA vaccine technology, pioneered by Katalin Karikó and Drew Weissman through their modified nucleoside work, enabled the rapid development of COVID-19 vaccines by Pfizer-BioNTech and Moderna within 11 months—a speed record against any prior vaccine. Karikó's discovery that pseudouridine reduced immune activation by 100-fold compared to unmodified mRNA was a critical data point, allowing safe delivery without severe inflammation.
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