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Sucralose (Splenda)
Sucralose breaks down into a genotoxic compound that directly damages DNA—a 2023 study in the Journal of Toxicology found sucralose-6-acetate harms gut epithelial cells at levels far lower than typical consumption. This compound is 30% more reactive in the digestive tract than the average artificial sweetener, and additional research shows sucralose impairs glucose tolerance and alters gut microbiome composition.
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