High-fructose corn syrup promotes weight gain more aggressively than table sugar—Princeton research found rats given HFCS gained 40% more weight than those consuming equal calories of sucrose. This sweetener is metabolized primarily in the liver, driving fatty liver disease at rates 25% higher than the average sugar alternative, and its ubiquity in processed foods pushes daily fructose intake far beyond safe limits. While #4 Agave Nectar has even higher fructose, HFCS's sheer volume in the food supply makes it the bigger public health threat.

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