Centene Corporation

Centene Corporation dominates Medicaid managed care with 28 million low-income beneficiaries—5 times the membership of #7 Molina Healthcare. The $153 billion revenue organization serves 50% more members than Humana overall, while maintaining a medical loss ratio of 87.3% that is 2.1% lower than the typical government plan peer. Its ACA marketplace enrollment grew 22% in 2025, reaching 2.4 million lives and cementing its role as the largest Medicaid MCO nationwide.