"Starboy" — The Weeknd ft. Daft Punk

Over 2.9 billion streams. The Weeknd's collaboration with Daft Punk debuted at #1 on the Hot 100 in 2016 and became the fastest song to reach 100 million Spotify streams at the time. It marked The Weeknd's transition from dark R&B to pop stardom and set the stage for his "Blinding Lights" dominance. Source: Spotify Charts.