Nature's flashy headlines drive a replication crisis that overshadows its reputation, with 70% of published findings irreproducible. This rate is 40 percentage points worse than the average for top-tier journals like Science, where retractions are slower to accumulate. A 2022 study found Nature's results were 2.5 times more likely to fail replication than those in lower-ranked cell biology journals. While its citation count remains unmatched, the cost is severe erosion in scientific trust.

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