Lance Armstrong won seven consecutive Tour de France titles (1999-2005) while running the most sophisticated doping programme in cycling history. USADA's 2012 investigation described it as "the most successful doping programme sport has ever seen," involving EPO, blood transfusions, testosterone, and cortisone. Armstrong was stripped of all seven titles and received a lifetime ban. His Livestrong cancer charity — built on his "clean" image — was collateral damage.

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