He Jiankui's CRISPR Babies (2018)

He Jiankui's CRISPR babies represent the most notorious breach of research ethics in modern genetics. By modifying the embryos of twin girls, Lulu and Nana, to confer HIV resistance, he bypassed all ethical review and introduced unknown off-target mutations into the human germline, a risk profile that makes the MMR-autism fraud look tame in comparison. He was sentenced to three years in prison, and a survey found 70% of bioethicists condemned the experiment as reckless. The twins now face an uncertain future, with no peer-reviewed outcome data to guide their care.