The Silence of the Lambs

Jonathan Demme's 1991 psychological thriller is one of only three films to sweep all five major Academy Awards (Best Picture, Director, Actor, Actress, Screenplay). Jodie Foster's FBI trainee Clarice Starling faces Hannibal Lecter — voted the #1 villain in film history by the AFI — while hunting a serial killer. It grossed $272M worldwide and remains a cultural landmark.