Omega-3 Supplementation EPA and DHA

Omega-3 fatty acids EPA and DHA are precursors to specialized pro-resolving mediators that actively resolve inflammation rather than simply blocking it. A 2021 JAMA meta-analysis of 40 RCTs found 2 or more grams per day EPA plus DHA reduced CRP by 22 percent, IL-6 by 18 percent, and TNF-alpha by 14 percent. The REDUCE-IT trial showed 4g per day icosapentaenoic acid reduced cardiovascular events by 25 percent beyond statin therapy.