Curcumin with Piperine

Curcumin inhibits NF-kB, COX-2, and LOX inflammatory enzymes — some of the same targets as ibuprofen, but without the GI or cardiovascular side effects. Meta-analyses of randomized trials have found that curcumin supplementation lowers CRP, IL-6, and TNF-alpha levels. Curcumin has near-zero bioavailability on its own, but piperine from black pepper substantially increases absorption — a widely cited 1998 study found roughly a 2000 percent increase. Typical doses run 1000 to 3000mg of curcumin extract with a small amount of piperine.