Curcumin with Piperine

Curcumin directly inhibits NF-kB, COX-2, and LOX inflammatory enzymes, the same targets as ibuprofen but without GI or cardiovascular side effects. A 2017 Oncotarget meta-analysis of 15 RCTs found curcumin reduced CRP by 6.4mg per liter, IL-6 by 38 percent, and TNF-alpha by 33 percent. Curcumin has near-zero bioavailability on its own. Piperine from black pepper increases absorption by 2000 percent. Dose is 1000 to 3000mg curcumin extract with 20mg piperine.