Alcohol above 14 units per week drives chronic systemic inflammation through gut dysbiosis and increased intestinal permeability allowing bacterial lipopolysaccharide to enter circulation triggering endotoxin-driven inflammation. A 2021 Gut journal study of 21000 participants showed alcohol above 14 units per week associated with 42 percent higher CRP and 35 percent higher IL-6 versus non-drinkers. Reducing from moderate to low drinking reduces CRP by 25 to 35 percent within 4 weeks.
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