Taurine

Taurine is the most validated longevity compound for restoring age-related depletion, backed by a landmark 2023 *Science* paper (Yadav et al., DOI: 10.1126/science.abn9257). The study demonstrated that taurine levels drop significantly with age across species, and supplementing taurine extended mouse lifespan by 10–12%—12% in females, 10% in males—with compressible morbidity. This multifunctional compound addresses at least four aging hallmarks: it reversed DNA damage, restored telomerase activity, improved mitochondrial membrane potential, reduced senescent cell burden, and decreased inflammatory cytokines. Human relevance is strong: blood taurine levels in 60-year-olds are 80% lower than in 5-year-olds, and a 3-gram/day protocol restored levels to youthful ranges. Taurine's safety profile is exceptional—it is abundant in breast milk and consumed by billions in energy drinks without serious adverse effects. Typical longevity dosing is 2–6 grams/day OTC at low cost.