50 Cent vs. Ja Rule — Career Destruction

This wasn't a feud — it was an annihilation. 50 Cent dedicated the majority of Get Rich or Die Tryin' (12 million copies sold) to destroying Ja Rule. "Many Men" and "Wanksta" were thinly veiled shots. Eminem joined Team 50 with "Hail Mary." Dr. Dre produced the artillery. By 2004, Ja Rule's career was functionally over. Murder Inc. was investigated by the feds. 50 Cent didn't just win the beef; he erased a man's career while selling 30 million records. The most commercially successful destruction in rap history.