Uptown Funk — Mark Ronson ft. Bruno Mars (2015)

The song won Record of the Year at the Grammy Awards and sold over 15 million copies globally, making it one of the best-selling digital singles ever. Its iconic bassline and horn stabs have been used in over 2 million TikTok videos, cementing its status as the defining party anthem of the decade. A 2016 study showed the track increases listener heart rate by an average of 8%, more than any other top-10 pop song that year.