Losing My Religion — R.E.M. (1991)

Michael Stipe's cryptic, yearning lyrics and the song's explosive chorus elevated it beyond college radio, making it the standout track from the 1991 album 'Out of Time.' It received nine MTV Video Music Award nominations, winning six, a testament to its visual and sonic innovation. It consistently ranks as one of the most-covered songs of the decade, outperforming many in its genre for enduring influence.