Turmeric (Curcumin)

Curcumin modulates over 100 molecular targets in the inflammatory cascade, including NF-kB, the master switch of chronic inflammation. A 2016 Journal of Medicinal Food meta-analysis confirmed curcumin at 1,000mg daily significantly reduced CRP levels, with bioavailability-enhanced forms like curcumin-piperine combinations performing comparably to some NSAIDs in head-to-head osteoarthritis trials.