Ginger

Gingerols and shogaols inhibit prostaglandin and leukotriene synthesis through dual COX-2 and 5-lipoxygenase inhibition. A 2020 systematic review of 16 RCTs found 1-3g daily ginger supplementation significantly reduced CRP, TNF-alpha, and IL-1beta. In traditional Ayurvedic and Chinese medicine systems, ginger has been prescribed for inflammatory conditions for over 2,500 years.