President Trump is reportedly preparing to fire FDA Commissioner Marty Makary, a move that could ignite the most explosive politicization of drug approvals since the agency's 2022 fast-track overhaul. The dismissal would affect oversight of 5,000+ pending applications annually, creating a leadership vacuum that outpaces #7's AI-driven production concerns in regulatory urgency. Makary's tenure has seen a 12% reduction in approval times, a benchmark faster than the average for commissioners over the past decade. Critics argue that firing him now would undermine public confidence in vaccine safety reviews, which currently process 150 million doses per year. The report, citing three senior administration officials, suggests the president is acting on long-standing grievances over pandemic-era mandates.

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